https://www.tandfonline.com/doi/abs/10.1080/03014460.2022.2039292?fbclid=IwAR3r-X1dsBOP9noJv2HYMGj6ZHZZebSnU4zbhmt2Q2fMbpTZLbJT8yc-UQk&journalCode=iahb20
Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Northern Kazakhstan
Yeldar Ashirbekov
,
Arman Abaildayev
,
Alena Neupokoyeva
,
Zhaxylyk Sabitov
&
Maxat Zhabagin
Received 17 Sep 2021, Accepted 20 Jan 2022, Accepted author version posted online: 08 Feb 2022
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https://doi.org/10.1080/03014460.2022.2039292
Abstract
Background
Previous studies of the genetic polymorphism of the Y-chromosome of Kazakhs were focused on the Eastern, Central, Southern, and Western regions of Kazakhstan. In addition, many of these studies were limited to 17 Y-STR loci from the Yfiler.
Aim
To enrich the existing Kazakhstan Y-chromosome Haplotype Reference Database from the Northern Kazakh population data by a wide set of 27 Y-STR and investigate the population genetic relationships with previously published data.
Subjects and methods
27 Y-STR loci from the Yfiler Plus PCR Amplification Kit were analysed in 382 healthy unrelated Kazakh males from Northern Kazakhstan. Genetic polymorphism was analysed using Arlequin software.
Results
A total of 326 distinct haplotypes of the 27 Y-STR loci were observed in 382 individuals. The discrimination capacity (0.9982) and haplotype diversity (0.8534) were computed. A total of 168 alleles at single-copy loci were observed, and their frequencies ranged from 0.003 to 0.843. The pairwise genetic distance (RST) showed that the Northern Kazakh population is genetically distinct from the Chinese Kazakh population.
Conclusions
Genetic polymorphism shows that the potential value of 27 Y-STR loci for forensic casework in the Northern Kazakh population, and the current findings, might be beneficial for paternal lineages in the study of population genetics.