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ДНК-проект: общие вопросы

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ДНК династии Цин

Yan et al

House of Aisin Gioro is the imperial family of the last dynasty in Chinese history – Qing Dynasty (1644 

– 1911). Aisin Gioro family originated from Jurchen tribes and developed the Manchu people before 

they conquered China. By investigating the Y chromosomal short tandem repeats (STRs) of 7 modern 

male individuals who claim belonging to Aisin Gioro family (in which 3 have full records of pedigree), 

we found that 3 of them (in which 2 keep full pedigree, whose most recent  common ancestor is 

Nurgaci) shows very close relationship (1 – 2 steps of difference in 17 STR) and the haplotype is rare. 

We therefore conclude that this haplotype is the Y chromosome of the House of Aisin Gioro. Further 

tests  of  single  nucleotide  polymorphisms  (SNPs)  indicates  that  they  belong  to  Haplogroup 

C3b2b1*‐M401(xF5483),  although their  Y‐STR results  are  distant to the  “star  cluster”,  which  also 

belongs to the same haplogroup. This study forms the base for the pedigree research of the imperial 

family of Qing Dynasty by means of genetics.


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Там ориентируются на сданные образцы.

Образцов С2 очень мало. Мало кто может себе позволить Биг У.

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Наконец, опубликована статья по гаплогруппе G1, включая ценные данные по казахам-аргынам.


Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers

Abstract

Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South-West and Central Asia but reaches up to 80% frequency in some populations scattered within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1-GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians. The haplotype diversity, which decreased from West Iran to Central Asia, allows us to hypothesize that this rare haplogroup could have been carried by the expansion of Iranic speakers northwards to the Eurasian steppe and via founder effects became a predominant genetic component of some populations, including the Argyn tribe of the Kazakhs. The remarkable agreement between genetic and genealogical trees of Argyns allowed us to calibrate the molecular clock using a historical date (1405 AD) of the most recent common genealogical ancestor. The mutation rate for Y-chromosomal sequence data obtained was 0.78×10-9 per bp per year, falling within the range of published rates. The mutation rate for Y-chromosomal STRs was 0.0022 per locus per generation, very close to the so-called genealogical rate. The “clan-based” approach to estimating the mutation rate provides a third, middle way between direct farther-to-son comparisons and using archeologically known migrations, whose dates are subject to revision and of uncertain relationship to genetic events.

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О геногеографии и фолк-хистори

Интервью с руководителем лаборатории популяционной генетики Медико-генетического научного центра, проф. Е.В.Балановской


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Обстоятельное исследование сибирских народов по аутосомным снипам.

The complex admixture history and recent southern origins of Siberian populations

http://biorxiv.org/content/early/2015/04/30/018770

Irina Pugach , Rostislav Matveev , Viktor Spitsyn , Sergey Makarov , Innokentiy Novgorodov , Vladimir Osakovsky , Mark Stoneking , Brigitte Pakendorf 

Abstract

Although Siberia was inhabited by modern humans at an early stage, there is still debate over whether this area remained habitable during the extremely cold period of the Last Glacial Maximum or whether it was subsequently repopulated by peoples with a recent shared ancestry. Previous studies of the genetic history of Siberian populations were hampered by the extensive admixture that appears to have taken place among these populations, since commonly used methods assume a tree-like population history and at most single admixture events. We therefore developed a new method based on the covariance of ancestry components, which we validated with simulated data, in order to investigate this potentially complex admixture history and to distinguish the effects of shared ancestry from prehistoric migrations and contact. We furthermore adapted a previously devised method of admixture dating for use with multiple events of gene flow, and applied these methods to whole-genome genotype data from over 500 individuals belonging to 20 different Siberian ethnolinguistic groups. The results of these analyses indicate that there have indeed been multiple layers of admixture detectable in most of the Siberian populations, with considerable differences in the admixture histories of individual populations, and with the earliest events dated to not more than 4500 years ago. Furthermore, most of the populations of Siberia included here, even those settled far to the north, can be shown to have a southern origin. These results provide support for a recent population replacement in this region, with the northward expansions of different populations possibly being driven partly by the advent of pastoralism, especially reindeer domestication. These newly developed methods to analyse multiple admixture events should aid in the investigation of similarly complex population histories elsewhere.

 

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Число отцов-основателей современных жителей Азии пополнилось
http://xn--c1acc6aafa1c.xn--p1ai/?page_id=3559

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статья о времени жизни предков европейцев


Abstract

The proportion of Europeans descending from Neolithic farmers ~10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ~2.1–4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.

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Число отцов-основателей современных жителей Азии пополнилось

http://xn--c1acc6aafa1c.xn--p1ai/?page_id=3559

Если я не ошибаюсь,то вы кажется проводили ДНК генеалогию кыргызов в Кыргызстане..Случайно,среди них не было из басызов? :)

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Число отцов-основателей современных жителей Азии пополнилось

http://xn--c1acc6aafa1c.xn--p1ai/?page_id=3559

Если я не ошибаюсь,то вы кажется проводили ДНК генеалогию кыргызов в Кыргызстане..Случайно,среди них не было из басызов? :)

 

Не помню, надо статью посмотреть

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Число отцов-основателей современных жителей Азии пополнилось

http://xn--c1acc6aafa1c.xn--p1ai/?page_id=3559

Если я не ошибаюсь,то вы кажется проводили ДНК генеалогию кыргызов в Кыргызстане..Случайно,среди них не было из басызов? :)

 

Не помню, надо статью посмотреть

 

Был бы очень признателен.. :)

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